If you follow K-beauty trends, you have probably heard of PDRN — also known as "salmon DNA therapy" or by the popular brand name Rejuran. This injectable treatment has become one of the most requested skin procedures in Korea, with rapid market growth reported in recent years. But what exactly is PDRN, how does it work, and is it worth a trip to Korea? Let us break it down.
What Is PDRN?
PDRN stands for Polydeoxyribonucleotide. It is a biological compound extracted from salmon DNA (specifically, salmon sperm DNA). Before you react to that — this is an injectable with a long history in wound-healing medicine, not a beauty gimmick. PDRN has been used in wound healing and medical applications for over 20 years in Europe and Asia.
In aesthetic medicine, PDRN is injected into the skin where it:
- Stimulates cell regeneration: PDRN activates A2A purinergic receptors, accelerating the growth of new skin cells
- Boosts collagen production: It triggers fibroblasts (collagen-producing cells) to produce more type I and III collagen
- Reduces inflammation: PDRN has powerful anti-inflammatory properties that calm irritated, damaged skin
- Improves microcirculation: Enhanced blood flow delivers more nutrients to skin cells
The aim: skin that is thicker, more elastic and better hydrated, although results vary from person to person.
PDRN vs. Traditional Skin Treatments
How does PDRN compare to treatments you might already know?
| Treatment | Mechanism | Best For | Duration |
|---|---|---|---|
| PDRN / Rejuran | Cell regeneration + collagen | Overall skin quality | 6-12 months |
| Hyaluronic Acid (Skinbooster) | Hydration + volume | Dry, dehydrated skin | 4-6 months |
| Botox | Muscle relaxation | Dynamic wrinkles | 3-4 months |
| Retinol / Tretinoin | Cell turnover | Texture, fine lines | Ongoing use |
| Laser Resurfacing | Controlled damage + healing | Scars, pigmentation | Variable |
PDRN is unique because it improves the fundamental quality of your skin rather than just addressing specific symptoms. Some dermatologists call it a "skin foundation treatment" and use it alongside other procedures.
Types of PDRN Treatments Available in Korea
Korea offers several PDRN formulations, each designed for specific skin concerns:
- Rejuran Healer: The original and most popular. Improves overall skin quality, thickness, and elasticity. Ideal for general anti-aging
- Rejuran S (Scar): Higher concentration formula specifically designed for acne scars and textural irregularities
- Rejuran I (Eye): Thinner formulation for the delicate under-eye area. Targets dark circles, fine lines, and crepey skin around the eyes
- Rejuran HB: Combines PDRN with hyaluronic acid for dual hydration and regeneration benefits
- PDRN IV Therapy: Intravenous PDRN for systemic anti-aging effects. Increasingly popular among wellness tourists
The Treatment Process
Here is what to expect during a PDRN session in Korea:
- Consultation (30 min): Your dermatologist examines your skin condition, discusses goals, and recommends the appropriate PDRN type and concentration
- Numbing (20 min): Topical anesthetic cream is applied to minimize discomfort
- Injection (20-30 min): PDRN is injected using either manual micro-injections or a micro-needle device at precise depths in the dermis
- Aftercare: LED therapy or soothing mask may be applied. Most people return to normal activities the same day; redness or small bumps may last 1-3 days
Most protocols recommend 3-4 sessions, spaced 2-4 weeks apart, for optimal results.
Cost: Korea vs. Other Countries
| Country | Price Per Session (USD) |
|---|---|
| Korea | $150 – $350 |
| Singapore | $400 – $800 |
| Japan | $350 – $700 |
| USA (limited availability) | $500 – $1,000+ |
For a full course of 3-4 sessions in Korea, you would pay $450 – $1,400 total. The same treatment course in Singapore would cost $1,200 – $3,200. Savings: 50-70%.
Who Is PDRN Best For?
PDRN is remarkably versatile, but it is especially effective for:
- Ages 28-35: Preventative anti-aging — build collagen reserves before visible aging begins
- Ages 35-50: Active treatment — may help improve early signs of aging, improve skin texture and elasticity
- Acne scar sufferers: Rejuran S can significantly improve rolling and boxcar scars
- Post-procedure recovery: PDRN accelerates healing after laser treatments or other procedures
- Sensitive skin types: PDRN's anti-inflammatory properties make it one of the few injectable treatments suitable for reactive skin
Why Korea for PDRN?
Reasons people choose Korea for PDRN treatments:
- Birthplace of aesthetic PDRN: Korean researchers pioneered the use of PDRN in cosmetic dermatology
- Widest product range: All Rejuran variants are developed and manufactured in Korea. Some formulations are not yet available elsewhere
- Most experienced practitioners: PDRN treatments are very widely performed in Korea
- Combination protocols: Korean clinics often combine PDRN with complementary treatments such as lasers and skin boosters
Frequently Asked Questions
Does it hurt? With numbing cream, most patients describe mild discomfort — like tiny pinches. It is very tolerable.
When will I see results? Initial glow appears within 1-2 weeks. Full collagen regeneration builds over 4-8 weeks, with peak results at 3 months.
How long do results last? 6-12 months. Most patients do maintenance sessions every 6 months.
Are there side effects? Common: mild redness, swelling, bruising and small bumps at injection sites for 1-3 days. Less common: infection, lumps or an allergic reaction (the product is fish-derived). Ask your doctor about the risks before treatment.
Can I combine PDRN with other treatments? Often, yes. In Korea, PDRN is commonly combined with skin boosters or laser toning in the same session; your doctor will advise which combinations suit you.
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Curious about PDRN treatment for your specific skin concerns? Book a free consultation with MyDoc Korea. Send us photos of your skin and partner-clinic dermatologists will recommend a PDRN protocol for your goals.
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See prices, surgeons and FAQs for Skin Care Treatments in Korea
This article is general information prepared by MyDoc Korea's coordinators from partner-clinic information and published sources. Prices are typical Gangnam clinic ranges at the time of writing and vary by case; the treating clinic confirms the final price after your consultation. Last reviewed: .
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Medical Disclaimer
The information provided in this article is for general informational and educational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment. Individual results may vary.