PDRN (Polydeoxyribonucleotide) therapy, commonly known as Rejuran or "salmon DNA injections," has exploded in popularity across Korea and is now one of the most in-demand skin treatments of 2026. Derived from salmon DNA fragments, this treatment works at a cellular level to rejuvenate skin from within.
What Is PDRN and How Does It Work?
PDRN is a biological molecule extracted from salmon DNA that closely resembles human DNA structure. When injected into the skin, it activates cell regeneration and repair mechanisms, boosting collagen and elastin production naturally.
- Cellular regeneration: Activating dormant skin cells to produce new, healthy tissue
- Anti-inflammatory effects: Reducing redness and calming irritated skin
- Improved microcirculation: Enhancing blood flow for a natural glow
- Wound healing: Accelerating recovery from acne scars and damage
Clinical Benefits
Some studies on PDRN therapy have reported results such as the following (individual results vary):
- 47% improvement in skin hydration after a full treatment course
- 33% increase in skin elasticity within 3 months
- Significant reduction in fine lines and wrinkle depth
- Visible improvement in acne scarring and skin texture
PDRN vs Other Skin Boosters
| Treatment | Main Benefit | Duration | Best For |
| PDRN (Rejuran) | Cell regeneration | 6-12 months | Overall skin quality |
| Profhilo | Deep hydration | 6 months | Dehydrated, aging skin |
| Exosome products (topical) | Soothing and hydration (evidence limited) | Varies | Post-treatment care |
The Treatment Process
- Consultation (15 min): AI-powered skin analysis to identify target areas
- Numbing (20 min): Topical anesthetic cream for comfort
- Injection (30-45 min): Micro-injections across the face
- Post-care: LED therapy or soothing mask
Most patients need 3-4 sessions spaced 2-4 weeks apart for optimal results.
Cost in Korea vs Abroad
- Korea: $180-275 per session
- United States: $500-800 per session
- Singapore: $400-600 per session
- Australia: $450-700 per session
Who Is PDRN Best For?
- Those with dull, tired-looking skin seeking a natural glow
- Patients with early signs of aging
- Anyone with acne scarring or uneven texture
- Patients aged 25-55 for preventive or corrective care
Results Timeline
- Week 1: Initial hydration boost
- Week 2-3: Improved skin texture noticeable
- Month 1-2: Visible glow, reduced fine lines
- Month 3: Peak results with improved elasticity
Related Articles
- Rejuran Healer: Is the Pain Worth the Glow?
- Korean Skin Boosters Complete Guide
- PN vs PLLA: Korean Bio-Lifting Treatments
- Top 5 Skin Treatments Trending in Korea
- Acne Scar Treatment in Korea
Interested in PDRN treatment? Contact MyDoc Korea for a free consultation, and we will arrange a partner-clinic appointment where the doctor recommends a treatment plan.
Considering this treatment?
See prices, surgeons and FAQs for Skin Care Treatments in Korea
This article is general information prepared by MyDoc Korea's coordinators from partner-clinic information and published sources. Prices are typical Gangnam clinic ranges at the time of writing and vary by case; the treating clinic confirms the final price after your consultation. Last reviewed: .
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Medical Disclaimer
The information provided in this article is for general informational and educational purposes only and is not intended as, nor should it be considered a substitute for, professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment. Individual results may vary.